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Growth-Hormone-Releasing Hormone

Growth-Hormone-Releasing Hormone (GHRH) is a chain of 44 amino acids that is predominantly secreted by the hypothalamic neurons and is considered to be the main regulator of the pituitary somatotrophs. GHRH has attracted much attention amongst the sporting & fitness communities due to its ability to stimulate the body to secrete more growth hormone through binding to its G-protein-coupled receptor (GHRH-R) which activated signalling pathways in the body. The secretagogue has a beneficial effect over artificial GH as what it effectively does is tell your body through feedback loops that it must secrete and release more Growth Hormone. This is viewed as advantageous amongst some of the academic literature as instead of putting artificial GH in which may cause imbalances in your own production through negative feedback loops it instead interacts with those same feedback signals and tells your own body that it must release and produce more endogenous GH. 

The main role of growth hormone-releasing hormone is to stimulate the pituitary gland to produce and release growth hormone into the bloodstream. This then acts on virtually every tissue of the body to control metabolism and growth. Growth hormone stimulates production of insulin-like growth factor 1in the liver and other organs, and this acts on tissues in the body to control metabolism and growth. In addition to its effect on growth hormone secretion, growth hormone-releasing hormone also affects sleep, food intake and memory.

One of its best aspects however is its price…..given we have just spoke of how GHRH is capable of causing the body to release more growth hormone into the bloodstream which then causes a magnitude of overwhelmingly advantageous environment for the body to train and grow…..but it often comes at just a fraction of the price when compared to growth hormone.  

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